Home
HelpTest Code LAB555 Cerebrospinal Fluid IgG Index Profile, Serum and Spinal Fluid
Additional Codes
SQ: SFIGXM
MAYO: SFIG
Specimen Required
Both serum and spinal fluid are required. Spinal fluid must be obtained within 7 days of serum collection.
Two individual serum samples are required.
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: 2 Plastic vials
Specimen Volume: 2 mL in 2 plastic vials, each vial containing 1 mL
Collection Instructions: Centrifuge and aliquot serum into 2 plastic vials within 2 hours of collection.
Specimen Type: Spinal fluid
Container/Tube: Sterile vial
Specimen Volume: 1 mL
Collection Instructions: Label specimen as SFINC.
Secondary ID
610783Useful For
Aiding in the diagnosis of multiple sclerosis and other central nervous system inflammatory conditions
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| SFINC | IgG Index, CSF | No | Yes |
| SFIGS | IgG, S | No | Yes |
| ALBS1 | Albumin, S | Yes, (order ALB) | Yes |
Method Name
SFINC, SFIGS: Nephelometry
ALBS1: Photometric
Reporting Name
CSF IgG Index ProfileSpecimen Type
CSFSerum
Specimen Minimum Volume
Serum 1 mL in 2 plastic vials, each vial containing 0.5 mL
Spinal fluid: 0.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| CSF | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 14 days | ||
| Serum | Refrigerated (preferred) | 14 days | |
| Frozen | 28 days | ||
| Ambient | 7 days |
Reject Due To
| Criteria apply to serum specimens only. For CSF specimens, the criteria are not applicable. | |
| Gross hemolysis | Reject |
| Gross lipemia | Reject |
| Gross icterus | OK |
Reference Values
CSF index: 0.00-0.85
CSF IgG: 0.0-8.1 mg/dL
CSF albumin: 0.0-27.0 mg/dL
Serum IgG
0-4 months: 100-334 mg/dL
5-8 months: 164-588 mg/dL
9-14 months: 246-904 mg/dL
15-23 months: 313-1,170 mg/dL
2-3 years: 295-1,156 mg/dL
4-6 years: 386-1,470 mg/dL
7-9 years: 462-1,682 mg/dL
10-12 years: 503-1,719 mg/dL
13-15 years: 509-1,580 mg/dL
16-17 years: 487-1,327 mg/dL
≥18 years: 767-1,590 mg/dL
Serum albumin
≥12 months: 3,500-5,000 mg/dL
Reference values have not been established for patients who are <12 months of age.
CSF IgG/albumin: 0.00-0.21
Serum IgG/albumin: 0.0-0.4
CSF IgG synthesis rate: 0-12 mg/24 hours
Method Description
CSF IgG and albumin, and Serum IgG:
The cerebrospinal fluid (CSF) IgG and albumin, and serum IgG are determined by immunonephelometry. The CSF IgG index and synthesis rate are calculated and reported.(Instruction manual: Siemens BN II Nephelometer Operations. Siemens, Inc.; Version 2.3, 2008; Addendum to the Instruction Manual 2.3, 08/2017)
Serum albumin:
The dye, bromcresol green (BCG), is added to serum in an acid buffer. The color intensity of the blue-green albumin-BCG complex is directly proportional to the albumin concentration and is determined photometrically.(Package insert: Roche Albumin reagent. Roche Diagnostics; 03/2015)
Day(s) Performed
Monday through Friday
Report Available
2 to 5 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
82040
82042
82784 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SFIG | CSF IgG Index Profile | 14116-8 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| INDEX | IgG Index, CSF | 14117-6 |
| ALB_S | Albumin, S | 1751-7 |
| IGG_S | IgG, S | 2465-3 |
| AIGAS | IgG/Albumin, S | 6782-7 |
| IGG_C | IgG, CSF | 2464-6 |
| ALB_C | Albumin, CSF | 1746-7 |
| AIGAC | IgG/Albumin, CSF | 2470-3 |
| SRATE | Synthesis Rate, CSF | 14116-8 |