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HelpTest Code LAB3129 Voriconazole, Serum
Additional Codes
SQ: VORI
MAYO: VORI
Reporting Name
Voriconazole, SUseful For
Monitoring trough levels of voriconazole is suggested for:
-Individuals with reduced liver function
-Individuals with cytochrome P450 (CYP) 2C19 alterations associated with poor metabolic function
-Patients taking other medications that affect CYP2C19 activity
-Patients experiencing potential toxicity
Monitoring trough levels may be reasonable in patients who are not responding optimally or have drug interactions that may decrease voriconazole levels or to ensure adequate oral absorption
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Specimen Type
Serum RedSpecimen Required
Collection Container/Tube: Red top (serum gel/SST not acceptable)
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL
Collection Instructions: Centrifuge and aliquot serum into plastic vial within 2 hours of collection.
Specimen Minimum Volume
0.6 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum Red | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
1.0-5.5 mcg/mL
Trough level (ie, immediately before next dose) monitoring is recommended.
Day(s) Performed
Monday through Sunday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
80285
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| VORI | Voriconazole, S | 38370-3 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 88698 | Voriconazole, S | 38370-3 |
Method Description
The serum sample is diluted in an acetonitrile internal standard. The protein precipitate is centrifuged and a portion of the supernatant is diluted with mobile phase 1 for detection by a tandem mass spectrometer.(Unpublished Mayo method)
Report Available
Same day/1 to 2 daysReject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)