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HelpTest Code Epic LAB740 Oligoclonal Banding, Serum and Spinal Fluid
Additional Codes
SQ code SFOLGM
Mayo code OLIG
Reporting Name
Oligoclonal BandingSpecimen Type
CSFSerum
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Diagnosis of multiple sclerosis; especially useful in patients with equivocal clinical presentation and radiological findings
Specimen Required
Both serum and spinal fluid are required. Spinal fluid must be obtained within 7 days of serum collection.
Specimen Type: Serum
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 0.5 mL
Collection Instructions:
1. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.
2. Label specimen as serum.
Specimen Type: Spinal fluid
Container/Tube: Sterile vial
Specimen Volume: 0.5 mL
Collection Instructions: Label specimen as spinal fluid.
Specimen Minimum Volume
Serum, Spinal fluid: 0.4 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| CSF | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days | |
| Serum | Refrigerated (preferred) | 14 days |
| Ambient | 14 days | |
| Frozen | 14 days |
Reference Values
CSF Oligoclonal Bands Interpretation: <2 bands
Day(s) Performed
Monday through Friday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83916 x 2
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| OLIG | Oligoclonal Banding | 100757-4 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8017 | CSF Bands | 49852-7 |
| 2783 | Serum Bands | 100755-8 |
| 23611 | CSF Olig Bands Interpretation | 100756-6 |
Reject Due To
| Gross hemolysis | OK |
| Gross lipemia | OK |
| Gross icterus | OK |
Method Name
Isoelectric Focusing (IEF) with IgG Immunoblot Detection
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| OLIGS | Serum Bands | No | Yes |
| OLIGC | CSF Bands | No | Yes |
Method Description
The oligoclonal band (OCB) assay requires paired cerebrospinal fluid (CSF) and serum samples. Unconcentrated CSF and diluted serum are electrophoresed by isoelectric focusing. The separated immunoglobulins (Ig) are visualized by an IgG immunoblot, and OCBs that are present in the CSF and not in the serum are reported. The assay uses reagents from Helena Laboratories.(Package insert: SPIFE Touch IgG IEF Procedure. Helena Laboratories. 02/2024)