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Test Code Epic LAB498 Topiramate, Serum

Additional Codes

SQ code TOPIRM

Mayo code TOPI

Reporting Name

Topiramate, S

Specimen Type

Serum Red

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Monitoring serum concentrations of topiramate

 

Assessing compliance

 

Assessing potential toxicity


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Red top (serum gel/SST are not acceptable)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL serum

Collection Instructions:

1. Draw blood immediately before next scheduled dose.

2. Within 2 hours of collection, centrifuge and aliquot serum into a plastic vial.


Specimen Minimum Volume

Serum: 0.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Red Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

Anticonvulsant: 5.0-20.0 mcg/mL

Day(s) Performed

Monday through Friday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80201

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TOPI Topiramate, S 17713-9

 

Result ID Test Result Name Result LOINC Value
81546 Topiramate, S 17713-9

Reject Due To

Gross hemolysis OK
Gross lipemia OK
Gross icterus OK

Method Description

The serum sample is crashed with acetonitrile containing the deuterium labeled internal standard. The protein precipitate is centrifuged and a portion of the supernatant is diluted with Mobile Phase 1 for detection by tandem mass spectrometry (MS/MS).(Unpublished Mayo method)

Report Available

1 to 2 days

Secondary ID

81546

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Neurology Specialty Testing Client Test Request (T732)

-Therapeutics Test Request (T831)