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Test Code Epic LAB4422 Coccidioides Antibody Screen with Reflex, Serum

Additional Codes

SQ code COXIS

Mayo code COXIS

Reporting Name

Coccidioides Ab Screen w/Reflex, S

Specimen Type

Serum

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Detecting antibodies to Coccidioides immitis/posadasii

 

This assay should not be used for monitoring response to therapy.

Testing Algorithm

If result is reactive, then Coccidioides by complement fixation and immunodiffusion will be performed at an additional charge.

 

For more information see Meningitis/Encephalitis Panel Algorithm.


Specimen Required


Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.


Specimen Minimum Volume

1.7 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

Negative

 

Reference value applies to all ages

Day(s) Performed

Monday through Friday

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

86635

86635 x3 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
COXIS Coccidioides Ab Screen w/Reflex, S 40712-2

 

Result ID Test Result Name Result LOINC Value
COXQ2 Coccidioides Ab Screen, S 40712-2

Reject Due To

Gross hemolysis Reject
Gross lipemia Reject

Method Name

COXIS: Enzyme Immunoassay (EIA)

RSCOC: Complement Fixation (CF)/Immunodiffusion (ID)

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
RSCOC Coccidioides Ab, CompF/ImmDiff,S Yes, (order SCOC) No

Method Description

Microwells are coated with recombinant Coccidioides complement fixing (CF) and tube precipitin (TP) antigens. Diluted serum specimens and controls are incubated in the wells, and if present, antibodies to TP and CF will bind to the adhered antigen. Nonspecific reactants are removed by washing; peroxidase-conjugated, secondary antihuman antibody is then applied to the wells and incubated. The conjugated secondary antibody will bind to the patient antibodies. Substrate solution is added to the wells, activating the peroxidase conjugate to develop a color reaction. Stop solution is added and the color change is quantified by measuring the optical density.(Package insert: clarus Cocci AB EIA. Immy; Revision 03/06/2020)

Report Available

1 to 7 days

Secondary ID

62079

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.