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HelpTest Code Epic LAB3979 Thyrotropin Receptor Antibody, Serum
Additional Codes
SQ code THYREM
Mayo code THYRO
Reporting Name
Thyrotropin Receptor Ab, SSpecimen Type
SerumPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Useful For
Recommended first-line test for detection of thyrotropin receptor antibodies
Differential diagnosis of etiology of thyrotoxicosis in patients with ambiguous clinical findings and/or contraindicated (eg, pregnant or breast-feeding) or nondiagnostic thyroid radioisotope scans
Diagnosing clinically suspected Graves disease (GD) (eg, extrathyroidal manifestation of GD include endocrine exophthalmos, pretibial myxedema, thyroid acropachy) in patients with normal thyroid function tests
Determining the risk of neonatal thyrotoxicosis in a fetus of a pregnant female with active or past active GD
Differential diagnosis of gestational thyrotoxicosis versus first trimester manifestation or recurrence of GD
Assessing the risk of GD relapse after antithyroid drug treatment
Specimen Required
Patient Preparation:
1. For 12 hours before specimen collection. patient should not take multivitamins or dietary supplements (eg, hair, skin, and nail supplements) containing biotin (vitamin B7).
2. Patient should not be receiving heparin treatment.
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot serum into a plastic vial.
Specimen Minimum Volume
0.75 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 7 days |
| Frozen | 90 days |
Reference Values
≤1.75 IU/L
Day(s) Performed
Monday through Saturday
Test Classification
This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.CPT Code Information
83520
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| THYRO | Thyrotropin Receptor Ab, S | 5385-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| THYRO | Thyrotropin Receptor Ab, S | 5385-0 |
Reject Due To
| Gross hemolysis | Reject |
| Gross lipemia | OK |
| Gross icterus | Reject |
Method Name
Electrochemiluminescence Immunoassay
Method Description
The Roche TSHR (thyrotropin receptor antibody [TRAb]) assay is a competitive assay using electrochemiluminescence detection. Patient sample is treated with a reagent buffer consisting of a pre-formed immunocomplex of solubilized porcine thyrotropin (TSH) receptor and biotinylated anti-porcine TSH receptor mouse monoclonal antibody. TRAb in the patient's sample are allowed to interact with the TSH receptor complex. After addition of streptavidin-coated microparticles and a human thyroid-stimulating monoclonal autoantibody (M22) labeled with a ruthenium complex, bound TRAb are detected by their ability to inhibit the binding of labeled M22. The entire complex becomes bound to the solid phase via interaction of biotin and streptavidin. This reaction mixture is aspirated into a measuring cell where the bound microparticles are captured onto the electrode surface and unbound substances are removed. Voltage is applied to the electrode inducing a chemiluminescent emission, which is then measured against a calibration curve to determine the amount of thyrotropin receptor antibody in the patient specimen.(Package insert: Elecsys Anti-TSHR. Roche Diagnostics; V 3.0, 09/2023)
Report Available
1 to 3 daysForms
If not ordering electronically, complete, print, and send a General Request (T239) with the specimen.