Test Code Epic LAB2602 Metanephrines, Fractionated, Free, Plasma
Additional Codes
SQ code METPM
Mayo code PMET
Reporting Name
Metanephrines, Fract., Free, PSpecimen Type
Plasma EDTAPerforming Laboratory
Mayo Clinic Laboratories in RochesterUseful For
Screening test for presumptive diagnosis of catecholamine-secreting pheochromocytomas or paragangliomas
Specimen Required
Patient Preparation: Use of an Epi-pen within the last 7 days may produce inaccurate results.
Collection Container/Tube: Lavender top (EDTA)
Submission Container/Tube: Plastic vial
Specimen Volume: 1 mL
Collection Instructions: Centrifuge and aliquot plasma into a plastic vial within 2 hours of collection.
Specimen Minimum Volume
0.3 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Plasma EDTA | Frozen (preferred) | 28 days | |
Refrigerated | 14 days | ||
Ambient | 7 days |
Reference Values
METANEPHRINE, FREE
<0.50 nmol/L
NORMETANEPHRINE, FREE
<0.90 nmol/L
Day(s) Performed
Monday through Saturday
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
83835
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
PMET | Metanephrines, Fract., Free, P | 57772-6 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
10140 | Normetanephrine, Free | 40851-8 |
10139 | Metanephrine, Free | 49700-8 |
Reject Due To
Gross hemolysis | Reject |
Gross lipemia | OK |
Gross icterus | OK |
Method Name
Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)
Method Description
Free metanephrine and normetanephrine are extracted from plasma using solid phase extraction. The concentrated eluate is analyzed using liquid chromatography tandem mass spectrometry and quantified using stable isotope-labeled internal standards, d3-metanephrine and d3-normetanephrine.(Taylor RL, Singh RJ: Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma. Clin Chem. 2002;48[3]:533-539)
Report Available
2 to 5 daysForms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-General Request (T239)
-Oncology Test Request (T729)