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Test Code Epic LAB2602 Metanephrines, Fractionated, Free, Plasma

Additional Codes

SQ code METPM

Mayo code PMET

Reporting Name

Metanephrines, Fract., Free, P

Specimen Type

Plasma EDTA

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Useful For

Screening test for presumptive diagnosis of catecholamine-secreting pheochromocytomas or paragangliomas


Specimen Required


Patient Preparation: Use of an Epi-pen within the last 7 days may produce inaccurate results.

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot plasma into a plastic vial within 2 hours of collection.


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Frozen (preferred) 28 days
  Refrigerated  14 days
  Ambient  7 days

Reference Values

METANEPHRINE, FREE

<0.50 nmol/L

 

NORMETANEPHRINE, FREE

<0.90 nmol/L

Day(s) Performed

Monday through Saturday

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83835

LOINC Code Information

Test ID Test Order Name Order LOINC Value
PMET Metanephrines, Fract., Free, P 57772-6

 

Result ID Test Result Name Result LOINC Value
10140 Normetanephrine, Free 40851-8
10139 Metanephrine, Free 49700-8

Reject Due To

Gross hemolysis Reject
Gross lipemia OK
Gross icterus OK

Method Name

Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS)

Method Description

Free metanephrine and normetanephrine are extracted from plasma using solid phase extraction. The concentrated eluate is analyzed using liquid chromatography tandem mass spectrometry and quantified using stable isotope-labeled internal standards, d3-metanephrine and d3-normetanephrine.(Taylor RL, Singh RJ: Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma. Clin Chem. 2002;48[3]:533-539)

Report Available

2 to 5 days

Forms

If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-General Request (T239)

-Oncology Test Request (T729)